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| 1st(1st leg) | Atlante | - | Atlético Morelia | 0:0 (0:0) | ||
| 2nd (2nd leg) | Atlético Morelia | - | Atlante | 1:0 (0:0) | ||
| 1st(1st leg): 05/05/2022 03:00 | 2nd (2nd leg): 07/05/2022 23:00 | Winner: Atlético Morelia | ||||
| 1st(1st leg) | Cimarrones de Sonora | - | Club Celaya | 1:0 (0:0) | ||
| 2nd (2nd leg) | Club Celaya | - | Cimarrones de Sonora | 1:1 (1:0) | ||
| 1st(1st leg): 06/05/2022 03:00 | 2nd (2nd leg): 08/05/2022 22:00 | Winner: Cimarrones de Sonora | ||||
