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| 1st(1st leg) | Mineros de Zacatecas | - | Atlético Morelia | 3:3 (1:2) | ||
| 2nd (2nd leg) | Atlético Morelia | - | Mineros de Zacatecas | 2:2 (1:1) | ||
| 1st(1st leg): 27/04/2022 01:00 | 2nd (2nd leg): 29/04/2022 23:00 | Winner: Atlético Morelia | ||||
| 1st(1st leg) | Cimarrones de Sonora | - | Alebrijes de Oaxaca | 1:0 dec. | ||
| 2nd (2nd leg) | Alebrijes de Oaxaca | - | Cimarrones de Sonora | 0:0 (0:0) | ||
| 1st(1st leg): 27/04/2022 03:05 | 2nd (2nd leg): 30/04/2022 23:00 | Winner: Cimarrones de Sonora | ||||
| 1st(1st leg) | Atlante | - | Leones Negros | 2:0 (0:0) | ||
| 2nd (2nd leg) | Leones Negros | - | Atlante | 1:2 (1:1) | ||
| 1st(1st leg): 29/04/2022 01:00 | 2nd (2nd leg): 01/05/2022 22:00 | Winner: Atlante | ||||
| 1st(1st leg) | Cancún FC | - | Club Celaya | 0:1 (0:0) | ||
| 2nd (2nd leg) | Club Celaya | - | Cancún FC | 2:1 (2:1) | ||
| 1st(1st leg): 29/04/2022 03:05 | 2nd (2nd leg): 02/05/2022 00:05 | Winner: Club Celaya | ||||
