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| 1st(1st leg) | Inter Playa | - | Cafetaleros de Chiapas | 3:1 (1:1) | ||
| 2nd (2nd leg) | Cafetaleros de Chiapas | - | Inter Playa | 3:5 (0:0, 3:1, 3:1) pso | ||
| 1st(1st leg): 09/12/2021 21:00 | 2nd (2nd leg): 13/12/2021 00:00 | Winner: Inter Playa | ||||
| 1st(1st leg) | Alacranes de Durango | - | Mazorqueros | 0:0 (0:0) | ||
| 2nd (2nd leg) | Mazorqueros | - | Alacranes de Durango | 0:2 (0:1) | ||
| 1st(1st leg): 10/12/2021 02:00 | 2nd (2nd leg): 12/12/2021 21:45 | Winner: Alacranes de Durango | ||||
