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| 1st(1st leg) | Club Calor | - | Mazorqueros | 1:0 (1:0) | ||
| 2nd (2nd leg) | Mazorqueros | - | Club Calor | 0:2 (0:1) | ||
| 1st(1st leg): 03/11/2022 01:00 | 2nd (2nd leg): 05/11/2022 22:00 | Winner: Club Calor | ||||
| 1st(1st leg) | Pioneros de Cancún | - | Alebrijes de Oaxaca II | 1:2 (0:1) | ||
| 2nd (2nd leg) | Alebrijes de Oaxaca II | - | Pioneros de Cancún | 1:0 (0:0) | ||
| 1st(1st leg): 03/11/2022 01:00 | 2nd (2nd leg): 06/11/2022 00:00 | Winner: Alebrijes de Oaxaca II | ||||
