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| 1st(1st leg) | Cruz Azul Hidalgo | - | Club Irapuato | 0:0 (0:0) | ||
| 2nd (2nd leg) | Club Irapuato | - | Cruz Azul Hidalgo | 1:1 (0:0) | ||
| 1st(1st leg): 24/04/2019 22:00 | 2nd (2nd leg): 28/04/2019 01:00 | Winner: Cruz Azul Hidalgo | ||||
| 1st(1st leg) | Tuxtla FC | - | Loros UCOL | 1:3 (1:2) | ||
| 2nd (2nd leg) | Loros UCOL | - | Tuxtla FC | 2:1 (1:0) | ||
| 1st(1st leg): 24/04/2019 22:00 | 2nd (2nd leg): 27/04/2019 22:00 | Winner: Loros UCOL | ||||
| 1st(1st leg) | Tuzos de la UAZ | - | Tepatitlán | 2:1 (1:0) | ||
| 2nd (2nd leg) | Tepatitlán | - | Tuzos de la UAZ | 2:2 (1:1) | ||
| 1st(1st leg): 25/04/2019 23:00 | 2nd (2nd leg): 28/04/2019 23:00 | Winner: Tuzos de la UAZ | ||||
| 1st(1st leg) | Dorados UACH | - | Atlético Reynosa | 2:2 (0:0) | ||
| 2nd (2nd leg) | Atlético Reynosa | - | Dorados UACH | 1:0 (1:0) | ||
| 1st(1st leg): 26/04/2019 01:00 | 2nd (2nd leg): 29/04/2019 00:00 | Winner: Atlético Reynosa | ||||
