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| 1st(1st leg) | Jaguares Chiapas | - | Cruz Azul | 1:0 (0:0) | ||
| 2nd (2nd leg) | Cruz Azul | - | Jaguares Chiapas | 2:1 (0:0) | ||
| 1st(1st leg): 15/05/2008 01:00 | 2nd (2nd leg): 17/05/2008 23:00 | Winner: Jaguares Chiapas | ||||
| 1st(1st leg) | CF Monterrey | - | Deportivo Guadalajara | 4:1 (2:1) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | CF Monterrey | 4:4 (2:2) | ||
| 1st(1st leg): 15/05/2008 03:00 | 2nd (2nd leg): 18/05/2008 02:00 | Winner: CF Monterrey | ||||
| 1st(1st leg) | Deportivo Toluca | - | Club San Luis | 1:1 (0:1) | ||
| 2nd (2nd leg) | Club San Luis | - | Deportivo Toluca | 0:0 (0:0) | ||
| 1st(1st leg): 16/05/2008 01:00 | 2nd (2nd leg): 18/05/2008 18:00 | Winner: Club San Luis | ||||
| 1st(1st leg) | Club Necaxa | - | Santos Laguna | 1:2 (1:1) | ||
| 2nd (2nd leg) | Santos Laguna | - | Club Necaxa | 1:1 (0:0) | ||
| 1st(1st leg): 16/05/2008 03:00 | 2nd (2nd leg): 18/05/2008 23:00 | Winner: Santos Laguna | ||||
