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| 1st(1st leg) | CF Pachuca | - | CF Monterrey | 1:0 (1:0) | ||
| 2nd (2nd leg) | CF Monterrey | - | CF Pachuca | 1:2 (1:0) | ||
| 1st(1st leg): 01/05/2010 23:00 | 2nd (2nd leg): 09/05/2010 00:00 | Winner: CF Pachuca | ||||
| 1st(1st leg) | Monarcas Morelia | - | Deportivo Guadalajara | 4:2 (1:2) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | Monarcas Morelia | 0:1 (0:0) | ||
| 1st(1st leg): 02/05/2010 01:00 | 2nd (2nd leg): 09/05/2010 02:00 | Winner: Monarcas Morelia | ||||
| 1st(1st leg) | Santos Laguna | - | Pumas UNAM | 2:0 (1:0) | ||
| 2nd (2nd leg) | Pumas UNAM | - | Santos Laguna | 1:0 (0:0) | ||
| 1st(1st leg): 03/05/2010 01:00 | 2nd (2nd leg): 09/05/2010 23:00 | Winner: Santos Laguna | ||||
| 1st(1st leg) | CF América | - | Deportivo Toluca | 2:2 (2:2) | ||
| 2nd (2nd leg) | Deportivo Toluca | - | CF América | 2:0 (1:0) | ||
| 1st(1st leg): 03/05/2010 03:00 | 2nd (2nd leg): 09/05/2010 18:00 | Winner: Deportivo Toluca | ||||
