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| 1st(1st leg) | Gallos Blancos | - | Cruz Azul | 0:2 (0:1) | ||
| 2nd (2nd leg) | Cruz Azul | - | Gallos Blancos | 1:1 (1:0) | ||
| 1st(1st leg): 29/11/2018 01:00 | 2nd (2nd leg): 02/12/2018 01:00 | Winner: Cruz Azul | ||||
| 1st(1st leg) | CF Monterrey | - | Santos Laguna | 1:0 (0:0) | ||
| 2nd (2nd leg) | Santos Laguna | - | CF Monterrey | 0:2 (0:0) | ||
| 1st(1st leg): 29/11/2018 03:06 | 2nd (2nd leg): 02/12/2018 03:00 | Winner: CF Monterrey | ||||
| 1st(1st leg) | Deportivo Toluca | - | CF América | 2:2 (1:2) | ||
| 2nd (2nd leg) | CF América | - | Deportivo Toluca | 3:2 (2:0) | ||
| 1st(1st leg): 30/11/2018 01:00 | 2nd (2nd leg): 03/12/2018 00:30 | Winner: CF América | ||||
| 1st(1st leg) | UANL Tigres | - | Pumas UNAM | 2:1 (0:1) | ||
| 2nd (2nd leg) | Pumas UNAM | - | UANL Tigres | 3:1 (0:0) | ||
| 1st(1st leg): 30/11/2018 03:00 | 2nd (2nd leg): 02/12/2018 18:00 | Winner: Pumas UNAM | ||||
