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| 1st(1st leg) | Santos Laguna | - | CF Monterrey | 0:0 (0:0) | ||
| 2nd (2nd leg) | CF Monterrey | - | Santos Laguna | 2:0 (1:0) | ||
| 1st(1st leg): 11/05/2023 02:00 | 2nd (2nd leg): 14/05/2023 02:06 | Winner: CF Monterrey | ||||
| 1st(1st leg) | Atlético San Luis | - | CF América | 1:3 (1:3) | ||
| 2nd (2nd leg) | CF América | - | Atlético San Luis | 1:2 (0:2) | ||
| 1st(1st leg): 11/05/2023 04:10 | 2nd (2nd leg): 14/05/2023 04:16 | Winner: CF América | ||||
| 1st(1st leg) | Atlas Guadalajara | - | Deportivo Guadalajara | 1:0 (1:0) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | Atlas Guadalajara | 1:0 (0:0) | ||
| 1st(1st leg): 12/05/2023 02:00 | 2nd (2nd leg): 15/05/2023 02:05 | |||||
| 1st(1st leg) | UANL Tigres | - | Deportivo Toluca | 4:1 (3:1) | ||
| 2nd (2nd leg) | Deportivo Toluca | - | UANL Tigres | 3:1 (2:0) | ||
| 1st(1st leg): 12/05/2023 04:10 | 2nd (2nd leg): 14/05/2023 19:00 | Winner: UANL Tigres | ||||
