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| 1st(1st leg) | Atlas Guadalajara | - | Monarcas Morelia | 1:2 (1:1) | ||
| 2nd (2nd leg) | Monarcas Morelia | - | Atlas Guadalajara | 1:2 (1:2) | ||
| 1st(1st leg): 27/11/2019 17:00 | 2nd (2nd leg): 30/11/2019 16:00 | |||||
| 1st(1st leg) | Club León | - | Deportivo Guadalajara | 0:3 (0:3) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | Club León | 3:2 (2:1) | ||
| 1st(1st leg): 28/11/2019 15:00 | 2nd (2nd leg): 01/12/2019 17:00 | Winner: Deportivo Guadalajara | ||||
| 1st(1st leg) | Cruz Azul | - | CF Pachuca | 1:4 (0:1) | ||
| 2nd (2nd leg) | CF Pachuca | - | Cruz Azul | 3:0 (2:0) | ||
| 1st(1st leg): 28/11/2019 16:00 | 2nd (2nd leg): 01/12/2019 16:00 | Winner: CF Pachuca | ||||
| 1st(1st leg) | Club Tijuana | - | Santos Laguna | 3:0 (2:0) | ||
| 2nd (2nd leg) | Santos Laguna | - | Club Tijuana | 1:2 (0:2) | ||
| 1st(1st leg): 29/11/2019 05:00 | 2nd (2nd leg): 01/12/2019 15:00 | Winner: Club Tijuana | ||||
