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| 1st(1st leg) | Pumas UNAM | - | Atlas Guadalajara | 3:2 (2:2) | ||
| 2nd (2nd leg) | Atlas Guadalajara | - | Pumas UNAM | 4:0 (0:0) | ||
| 1st(1st leg): 11/05/2022 16:00 | 2nd (2nd leg): 14/05/2022 15:00 | Winner: Atlas Guadalajara | ||||
| 1st(1st leg) | Club Tijuana | - | Santos Laguna | 1:1 (0:0) | ||
| 2nd (2nd leg) | Santos Laguna | - | Club Tijuana | 4:1 (1:1) | ||
| 1st(1st leg): 12/05/2022 20:45 | 2nd (2nd leg): 15/05/2022 16:00 | Winner: Santos Laguna | ||||
