 |
 |
|
|
| 1st(1st leg) | CF América | - | Deportivo Toluca | 1:1 (0:0) | ||
| 2nd (2nd leg) | Deportivo Toluca | - | CF América | 0:1 (0:1) | ||
| 1st(1st leg): 13/10/2022 15:00 | 2nd (2nd leg): 16/10/2022 17:30 | Winner: CF América | ||||
| 1st(1st leg) | Atlas Guadalajara | - | CF Pachuca | 1:0 (0:0) | ||
| 2nd (2nd leg) | CF Pachuca | - | Atlas Guadalajara | 2:0 (1:0) | ||
| 1st(1st leg): 13/10/2022 15:00 | 2nd (2nd leg): 16/10/2022 15:00 | Winner: CF Pachuca | ||||
