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| 1st(1st leg) | Santos Laguna | - | Atlas Guadalajara | 1:2 (1:1) | ||
| 2nd (2nd leg) | Atlas Guadalajara | - | Santos Laguna | 3:3 (2:0) | ||
| 1st(1st leg): 05/10/2022 15:00 | 2nd (2nd leg): 08/10/2022 17:30 | Winner: Atlas Guadalajara | ||||
| 1st(1st leg) | CF América | - | Deportivo Guadalajara | 2:1 (2:0) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | CF América | 1:2 (1:1) | ||
| 1st(1st leg): 05/10/2022 17:00 | 2nd (2nd leg): 08/10/2022 16:00 | Winner: CF América | ||||
| 1st(1st leg) | Pumas UNAM | - | Deportivo Toluca | 0:1 (0:0) | ||
| 2nd (2nd leg) | Deportivo Toluca | - | Pumas UNAM | 2:0 (0:0) | ||
| 1st(1st leg): 06/10/2022 16:00 | 2nd (2nd leg): 09/10/2022 17:30 | Winner: Deportivo Toluca | ||||
| 1st(1st leg) | Club Tijuana | - | CF Pachuca | 2:1 (2:1) | ||
| 2nd (2nd leg) | CF Pachuca | - | Club Tijuana | 2:1 (1:0) | ||
| 1st(1st leg): 07/10/2022 05:00 | 2nd (2nd leg): 09/10/2022 15:00 | |||||
