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| 1st(1st leg) | Monarcas Morelia | - | Club León | 3:2 (1:0) | ||
| 2nd (2nd leg) | Club León | - | Monarcas Morelia | 2:0 (2:0) | ||
| 1st(1st leg): 28/11/2018 16:00 | 2nd (2nd leg): 01/12/2018 16:00 | Winner: Club León | ||||
| 1st(1st leg) | Club Tijuana | - | Deportivo Guadalajara | 1:1 (0:0) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | Club Tijuana | 3:1 (1:1) | ||
| 1st(1st leg): 29/11/2018 04:00 | 2nd (2nd leg): 01/12/2018 18:00 | Winner: Deportivo Guadalajara | ||||
| 1st(1st leg) | Atlas Guadalajara | - | CF América | 2:1 (1:1) | ||
| 2nd (2nd leg) | CF América | - | Atlas Guadalajara | 3:2 (1:1) | ||
| 1st(1st leg): 29/11/2018 15:00 | 2nd (2nd leg): 02/12/2018 17:00 | Winner: Atlas Guadalajara | ||||
| 1st(1st leg) | CF Monterrey | - | Deportivo Toluca | 1:1 (0:0) | ||
| 2nd (2nd leg) | Deportivo Toluca | - | CF Monterrey | 0:2 (0:1) | ||
| 1st(1st leg): 29/11/2018 18:00 | 2nd (2nd leg): 02/12/2018 15:00 | Winner: CF Monterrey | ||||
