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| 1st(1st leg) | CF América | - | Atlas Guadalajara | 1:2 (0:1) | ||
| 2nd (2nd leg) | Atlas Guadalajara | - | CF América | 2:2 (2:1) | ||
| 1st(1st leg): 12/10/2022 15:00 | 2nd (2nd leg): 15/10/2022 15:00 | Winner: Atlas Guadalajara | ||||
| 1st(1st leg) | Pumas UNAM | - | CF Pachuca | 1:2 (1:0) | ||
| 2nd (2nd leg) | CF Pachuca | - | Pumas UNAM | 0:3 (0:2) | ||
| 1st(1st leg): 13/10/2022 16:00 | 2nd (2nd leg): 16/10/2022 18:00 | Winner: Pumas UNAM | ||||
