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| 1st(1st leg) | Club León | - | CF América | 0:1 (0:0) | ||
| 2nd (2nd leg) | CF América | - | Club León | 3:3 (1:0) | ||
| 1st(1st leg): 05/10/2022 15:00 | 2nd (2nd leg): 08/10/2022 15:00 | Winner: CF América | ||||
| 1st(1st leg) | Puebla FC | - | Atlas Guadalajara | 0:0 (0:0) | ||
| 2nd (2nd leg) | Atlas Guadalajara | - | Puebla FC | 1:1 (0:0) | ||
| 1st(1st leg): 05/10/2022 16:00 | 2nd (2nd leg): 08/10/2022 15:00 | Winner: Puebla FC | ||||
| 1st(1st leg) | Pumas UNAM | - | UANL Tigres | 3:1 (1:1) | ||
| 2nd (2nd leg) | UANL Tigres | - | Pumas UNAM | 1:2 (1:1) | ||
| 1st(1st leg): 05/10/2022 16:00 | 2nd (2nd leg): 08/10/2022 17:15 | Winner: Pumas UNAM | ||||
| 1st(1st leg) | Santos Laguna | - | CF Pachuca | 0:0 (0:0) | ||
| 2nd (2nd leg) | CF Pachuca | - | Santos Laguna | 1:0 (0:0) | ||
| 1st(1st leg): 06/10/2022 17:00 | 2nd (2nd leg): 09/10/2022 18:00 | Winner: CF Pachuca | ||||
