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| 1st(1st leg) | Gallos Blancos | - | CF América | 0:1 (0:1) | ||
| 2nd (2nd leg) | CF América | - | Gallos Blancos | 2:1 (0:0) | ||
| 1st(1st leg): 03/05/2023 16:00 | 2nd (2nd leg): 06/05/2023 16:00 | Winner: CF América | ||||
| 1st(1st leg) | Puebla FC | - | Atlas Guadalajara | 1:3 (1:2) | ||
| 2nd (2nd leg) | Atlas Guadalajara | - | Puebla FC | 3:2 (1:0) | ||
| 1st(1st leg): 03/05/2023 17:00 | 2nd (2nd leg): 06/05/2023 16:00 | Winner: Atlas Guadalajara | ||||
| 1st(1st leg) | Santos Laguna | - | Deportivo Guadalajara | 3:4 (2:3) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | Santos Laguna | 2:2 (0:1) | ||
| 1st(1st leg): 03/05/2023 18:00 | 2nd (2nd leg): 06/05/2023 18:30 | Winner: Deportivo Guadalajara | ||||
| 1st(1st leg) | UANL Tigres | - | Deportivo Toluca | 1:0 (1:0) | ||
| 2nd (2nd leg) | Deportivo Toluca | - | UANL Tigres | 2:1 (0:0) | ||
| 1st(1st leg): 04/05/2023 16:00 | 2nd (2nd leg): 07/05/2023 15:00 | Winner: UANL Tigres | ||||
