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| 13/11/2010 | 12:00 | FK Pelister | - | FK Turnovo | 2:0 (1:0) | |
| 12:00 | FK Renova | - | Vardar Skopje | 4:0 (1:0) | ||
| 12:00 | Sileks Kratovo | - | FK Skopje | 0:0 (0:0) | ||
| 12:00 | Metalurg Skopje | - | Napredok Kičevo | 1:2 (1:1) | ||
| 12:00 | FK Rabotnički | - | KF Shkëndija 79 | 1:1 (1:0) | ||
| 12:00 | FK Bregalnica Štip | - | FK Teteks | 1:0 (1:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkëndija 79 | 14 | 7 | 4 | 3 | 22:8 | 14 | 25 |
| 2 |
|
FK Renova | 14 | 7 | 4 | 3 | 16:8 | 8 | 25 |
| 3 |
|
Metalurg Skopje | 14 | 6 | 5 | 3 | 16:9 | 7 | 23 |
| 4 |
|
FK Teteks | 14 | 6 | 5 | 3 | 15:9 | 6 | 23 |
| 5 |
|
FK Turnovo | 14 | 7 | 1 | 6 | 16:14 | 2 | 22 |
| 6 |
|
Napredok Kičevo | 14 | 6 | 3 | 5 | 16:14 | 2 | 21 |
| 7 |
|
FK Rabotnički | 14 | 5 | 5 | 4 | 16:14 | 2 | 20 |
| 8 |
|
FK Skopje | 14 | 5 | 4 | 5 | 11:10 | 1 | 19 |
| 9 |
|
Sileks Kratovo | 14 | 5 | 4 | 5 | 15:18 | -3 | 19 |
| 10 |
|
FK Bregalnica Štip | 14 | 6 | 1 | 7 | 13:18 | -5 | 19 |
| 11 |
|
FK Pelister | 14 | 2 | 2 | 10 | 8:26 | -18 | 8 |
| 12 |
|
Vardar Skopje | 14 | 3 | 0 | 11 | 9:25 | -16 | 6 |
| Champions League Quali. | |
| Europa League | |
| Playoffs | |
| Relegation |
