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| 20/11/2010 | 12:00 | FK Bregalnica Štip | - | FK Pelister | 2:0 (0:0) | |
| 12:00 | FK Teteks | - | FK Rabotnički | 0:1 (0:0) | ||
| 12:00 | Napredok Kičevo | - | Sileks Kratovo | 1:0 (1:0) | ||
| 12:00 | FK Skopje | - | FK Renova | 0:1 (0:0) | ||
| 21/11/2010 | 12:00 | KF Shkëndija 79 | - | Metalurg Skopje | 3:0 (1:0) | |
| 12:00 | Vardar Skopje | - | FK Turnovo | 1:1 (0:1) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkëndija 79 | 15 | 8 | 4 | 3 | 25:8 | 17 | 28 |
| 2 |
|
FK Renova | 15 | 8 | 4 | 3 | 17:8 | 9 | 28 |
| 3 |
|
Napredok Kičevo | 15 | 7 | 3 | 5 | 17:14 | 3 | 24 |
| 4 |
|
FK Teteks | 15 | 6 | 5 | 4 | 15:10 | 5 | 23 |
| 5 |
|
Metalurg Skopje | 15 | 6 | 5 | 4 | 16:12 | 4 | 23 |
| 6 |
|
FK Rabotnički | 15 | 6 | 5 | 4 | 17:14 | 3 | 23 |
| 7 |
|
FK Turnovo | 15 | 7 | 2 | 6 | 17:15 | 2 | 23 |
| 8 |
|
FK Bregalnica Štip | 15 | 7 | 1 | 7 | 15:18 | -3 | 22 |
| 9 |
|
FK Skopje | 15 | 5 | 4 | 6 | 11:11 | 0 | 19 |
| 10 |
|
Sileks Kratovo | 15 | 5 | 4 | 6 | 15:19 | -4 | 19 |
| 11 |
|
FK Pelister | 15 | 2 | 2 | 11 | 8:28 | -20 | 8 |
| 12 |
|
Vardar Skopje | 15 | 3 | 1 | 11 | 10:26 | -16 | 7 |
| Champions League Quali. | |
| Europa League | |
| Playoffs | |
| Relegation |
