05/05/2022 18:00 Gudja United - Floriana FC 1:2 (0:1)
07/05/2022 15:00 Birkirkara FC - Hamrun Spartans 0:1 (0:1)
15:00 Gżira United - Hibernians FC 2:1 (1:1)
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# Team M. W D L goals Dif. Pt.
1 Hibernians FC, Malta Hibernians FC 27 15 9 3 46:23 23 54
2 Floriana FC, Malta Floriana FC 27 14 9 4 38:21 17 51
3 Hamrun Spartans, Malta Hamrun Spartans 27 13 6 8 33:24 9 45
4 Gżira United, Malta Gżira United 27 12 7 8 46:38 8 43
5 Birkirkara FC, Malta Birkirkara FC 27 10 11 6 35:27 8 41
6 Gudja United, Malta Gudja United 27 10 2 15 29:35 -6 32
  Champions League Quali.