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| 1. Round | ||||||
|---|---|---|---|---|---|---|
| 03/04/2022 | 17:00 | Floriana FC | - | Gżira United | 0:1 (0:1) | |
| 04/04/2022 | 16:00 | Hamrun Spartans | - | Hibernians FC | 2:1 (1:1) | |
| 19:15 | Birkirkara FC | - | Gudja United | 3:0 (2:0) | ||
| 2. Round | ||||||
| 09/04/2022 | 15:00 | Hibernians FC | - | Floriana FC | 0:0 (0:0) | |
| 10/04/2022 | 14:00 | Gżira United | - | Birkirkara FC | 1:1 (1:0) | |
| 17:15 | Gudja United | - | Hamrun Spartans | 1:0 (0:0) | ||
| 3. Round | ||||||
| 23/04/2022 | 15:00 | Birkirkara FC | - | Floriana FC | 0:0 (0:0) | |
| 24/04/2022 | 14:00 | Gudja United | - | Hibernians FC | 0:2 (0:0) | |
| 17:15 | Hamrun Spartans | - | Gżira United | 2:0 (1:0) | ||
| 4. Round | ||||||
| 30/04/2022 | 15:00 | Floriana FC | - | Hamrun Spartans | 0:0 (0:0) | |
| 01/05/2022 | 14:00 | Hibernians FC | - | Birkirkara FC | 3:1 (1:1) | |
| 17:15 | Gżira United | - | Gudja United | 3:1 (1:0) | ||
| 5. Round | ||||||
| 05/05/2022 | 18:00 | Gudja United | - | Floriana FC | 1:2 (0:1) | |
| 07/05/2022 | 15:00 | Birkirkara FC | - | Hamrun Spartans | 0:1 (0:1) | |
| 15:00 | Gżira United | - | Hibernians FC | 2:1 (1:1) | ||
