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| 1st(1st leg) | Roda JC Kerkrade | - | AFC Ajax | 0:3 (0:1) | ||
| 2nd (2nd leg) | AFC Ajax | - | Roda JC Kerkrade | 1:1 (1:0) | ||
| 1st(1st leg): 01/02/1978 | 2nd (2nd leg): 08/03/1978 | Winner: AFC Ajax | ||||
| 1st(1st leg) | BV Veendam | - | SBV Excelsior | 2:1 (1:0) | ||
| 2nd (2nd leg) | SBV Excelsior | - | BV Veendam | 3:0 (1:0) | ||
| 1st(1st leg): 01/02/1978 | 2nd (2nd leg): 05/02/1978 | Winner: SBV Excelsior | ||||
| 1st(1st leg) | WVV Wageningen | - | AZ '67 Alkmaar | 1:2 (0:0) | ||
| 2nd (2nd leg) | AZ '67 Alkmaar | - | WVV Wageningen | 1:0 (1:0) | ||
| 1st(1st leg): 05/02/1978 | 2nd (2nd leg): 01/03/1978 | Winner: AZ '67 Alkmaar | ||||
| 1st(1st leg) | ACV Vitesse | - | Sparta Rotterdam | 0:2 (0:1) | ||
| 2nd (2nd leg) | Sparta Rotterdam | - | ACV Vitesse | 2:0 (0:0) | ||
| 1st(1st leg): 01/03/1978 | 2nd (2nd leg): 15/03/1978 | Winner: Sparta Rotterdam | ||||
