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| 1st(1st leg) | AFC Ajax | - | FC Groningen | 3:0 (0:0) | ||
| 2nd (2nd leg) | FC Groningen | - | AFC Ajax | 1:1 (0:0) | ||
| 1st(1st leg): 25/02/1981 | 2nd (2nd leg): 18/03/1981 | Winner: AFC Ajax | ||||
| 1st(1st leg) | Go Ahead Eagles | - | PEC Zwolle | 1:1 (0:0) | ||
| 2nd (2nd leg) | PEC Zwolle | - | Go Ahead Eagles | 1:2 (0:0, 1:1) aet | ||
| 1st(1st leg): 25/02/1981 | 2nd (2nd leg): 21/03/1981 | Winner: Go Ahead Eagles | ||||
| 1st(1st leg) | SBV Haarlem | - | AZ '67 Alkmaar | 1:1 (1:1) | ||
| 2nd (2nd leg) | AZ '67 Alkmaar | - | SBV Haarlem | 3:1 (1:0) | ||
| 1st(1st leg): 25/02/1981 | 2nd (2nd leg): 01/04/1981 | Winner: AZ '67 Alkmaar | ||||
| 1st(1st leg) | Willem II | - | PSV Eindhoven | 0:1 (0:1) | ||
| 2nd (2nd leg) | PSV Eindhoven | - | Willem II | 2:0 (0:0) | ||
| 1st(1st leg): 25/02/1981 | 2nd (2nd leg): 11/03/1981 | Winner: PSV Eindhoven | ||||
