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| 1st(1st leg) | Sportlust '46 | - | Kozakken Boys | 0:0 (0:0) | ||
| 2nd (2nd leg) | Kozakken Boys | - | Sportlust '46 | 4:1 (0:1) | ||
| 1st(1st leg): 08/06/2022 19:00 | 2nd (2nd leg): 11/06/2022 14:00 | Winner: Kozakken Boys | ||||
| 1st(1st leg) | DVS'33 | - | USV Hercules | 5:2 (3:1) | ||
| 2nd (2nd leg) | USV Hercules | - | DVS'33 | 1:1 (0:0) | ||
| 1st(1st leg): 09/06/2022 19:00 | 2nd (2nd leg): 11/06/2022 17:00 | Winner: DVS'33 | ||||
| 1st(1st leg) | VV Gemert | - | GVVV | 1:2 (0:2) | ||
| 2nd (2nd leg) | GVVV | - | VV Gemert | 2:0 (1:0) | ||
| 1st(1st leg): 09/06/2022 19:00 | 2nd (2nd leg): 11/06/2022 17:00 | Winner: GVVV | ||||
| 1st(1st leg) | HSC'21 | - | Sparta Nijkerk | 1:0 (0:0) | ||
| 2nd (2nd leg) | Sparta Nijkerk | - | HSC'21 | 1:2 (0:2) | ||
| 1st(1st leg): 09/06/2022 19:00 | 2nd (2nd leg): 11/06/2022 17:00 | Winner: HSC'21 | ||||
