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| 1st(1st leg) | MVV | - | De Graafschap | 0:1 (0:0) | ||
| 2nd (2nd leg) | De Graafschap | - | MVV | 2:1 (1:1) | ||
| 1st(1st leg): 13/05/2016 17:30 | 2nd (2nd leg): 16/05/2016 11:30 | Winner: De Graafschap | ||||
| 1st(1st leg) | Go Ahead Eagles | - | VVV-Venlo | 1:0 (0:0) | ||
| 2nd (2nd leg) | VVV-Venlo | - | Go Ahead Eagles | 2:2 (2:1) | ||
| 1st(1st leg): 13/05/2016 18:45 | 2nd (2nd leg): 16/05/2016 13:30 | Winner: Go Ahead Eagles | ||||
| 1st(1st leg) | FC Eindhoven | - | NAC Breda | 1:0 (0:0) | ||
| 2nd (2nd leg) | NAC Breda | - | FC Eindhoven | 2:0 (2:0) | ||
| 1st(1st leg): 13/05/2016 18:45 | 2nd (2nd leg): 16/05/2016 13:30 | Winner: NAC Breda | ||||
| 1st(1st leg) | Almere City FC | - | Willem II | 0:1 (0:1) | ||
| 2nd (2nd leg) | Willem II | - | Almere City FC | 5:2 (1:0) | ||
| 1st(1st leg): 13/05/2016 19:45 | 2nd (2nd leg): 16/05/2016 15:45 | Winner: Willem II | ||||
