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| 11/02/2022 | 15:00 | Willem II | - | De Graafschap | 0:4 | |
| 16:45 | Koninklijke HFC | - | FC Dordrecht | 3:1 | ||
| 12/02/2022 | 12:15 | Almere City FC | - | Alphense Boys | 6:4 | |
| 14:00 | VVV-Venlo | - | SBV Excelsior | 3:0 |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Willem II | 13 | 10 | 0 | 3 | 43:24 | 19 | 30 |
| 2 |
|
De Graafschap | 13 | 8 | 2 | 3 | 42:15 | 27 | 26 |
| 3 |
|
Almere City FC | 13 | 6 | 3 | 4 | 42:30 | 12 | 21 |
| 4 |
|
VVV-Venlo | 13 | 4 | 4 | 5 | 21:22 | -1 | 16 |
| 5 |
|
Koninklijke HFC | 13 | 4 | 4 | 5 | 25:28 | -3 | 16 |
| 6 |
|
SBV Excelsior | 13 | 4 | 3 | 6 | 31:30 | 1 | 15 |
| 7 |
|
Alphense Boys | 13 | 4 | 3 | 6 | 23:43 | -20 | 15 |
| 8 |
|
FC Dordrecht | 13 | 1 | 3 | 9 | 14:49 | -35 | 6 |
| Promotion | |
| Relegation |
