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| 30/10/2021 | 11:30 | VVV-Venlo | - | Willem II | 3:1 | |
| 13:30 | De Graafschap | - | FC Dordrecht | 6:1 | ||
| 15:00 | Almere City FC | - | Koninklijke HFC | 7:0 | ||
| 31/10/2021 | 12:15 | SBV Excelsior | - | Alphense Boys | 6:0 |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Willem II | 8 | 7 | 0 | 1 | 27:12 | 15 | 21 |
| 2 |
|
De Graafschap | 8 | 4 | 2 | 2 | 28:10 | 18 | 14 |
| 3 |
|
SBV Excelsior | 8 | 4 | 1 | 3 | 21:14 | 7 | 13 |
| 4 |
|
VVV-Venlo | 8 | 3 | 3 | 2 | 14:15 | -1 | 12 |
| 5 |
|
Almere City FC | 8 | 3 | 2 | 3 | 24:15 | 9 | 11 |
| 6 |
|
Alphense Boys | 8 | 2 | 2 | 4 | 15:30 | -15 | 8 |
| 7 |
|
Koninklijke HFC | 8 | 1 | 3 | 4 | 15:24 | -9 | 6 |
| 8 |
|
FC Dordrecht | 8 | 1 | 1 | 6 | 7:31 | -24 | 4 |
| Promotion | |
| Relegation |
