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| 05/02/2022 | 12:00 | Willem II | - | SBV Excelsior | 1:2 (1:1) | |
| 13:30 | De Graafschap | - | PEC Zwolle | 0:1 (0:0) | ||
| 13:30 | Vitesse | - | FC Emmen | 2:2 (1:1) | ||
| 14:00 | Roda JC Kerkrade | - | Alphense Boys | 2:2 (1:2) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
PEC Zwolle | 12 | 8 | 2 | 2 | 24:10 | 14 | 26 |
| 2 |
|
Willem II | 12 | 7 | 2 | 3 | 26:15 | 11 | 23 |
| 3 |
|
SBV Excelsior | 12 | 6 | 1 | 5 | 15:12 | 3 | 19 |
| 4 |
|
De Graafschap | 12 | 5 | 3 | 4 | 22:16 | 6 | 18 |
| 5 |
|
FC Emmen | 12 | 3 | 4 | 5 | 17:21 | -4 | 13 |
| 6 |
|
Roda JC Kerkrade | 12 | 3 | 3 | 6 | 17:24 | -7 | 12 |
| 7 |
|
Vitesse | 12 | 3 | 3 | 6 | 16:24 | -8 | 12 |
| 8 |
|
Alphense Boys | 12 | 3 | 2 | 7 | 12:27 | -15 | 11 |
| Promotion | |
| Relegation |
