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| 16/10/2021 | 13:30 | PEC Zwolle | - | Roda JC Kerkrade | 1:2 (0:1) | |
| 13:30 | Willem II | - | De Graafschap | 1:2 (1:0) | ||
| 14:00 | SBV Excelsior | - | Vitesse | 0:1 (0:1) | ||
| 14:15 | Alphense Boys | - | FC Emmen | 0:0 (0:0) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Willem II | 6 | 3 | 1 | 2 | 12:9 | 3 | 10 |
| 2 |
|
PEC Zwolle | 6 | 3 | 1 | 2 | 9:6 | 3 | 10 |
| 3 |
|
Alphense Boys | 6 | 3 | 1 | 2 | 8:10 | -2 | 10 |
| 4 |
|
FC Emmen | 6 | 2 | 3 | 1 | 10:8 | 2 | 9 |
| 5 |
|
Roda JC Kerkrade | 6 | 2 | 2 | 2 | 9:10 | -1 | 8 |
| 6 |
|
Vitesse | 6 | 2 | 1 | 3 | 7:9 | -2 | 7 |
| 7 |
|
De Graafschap | 6 | 1 | 3 | 2 | 8:9 | -1 | 6 |
| 8 |
|
SBV Excelsior | 6 | 2 | 0 | 4 | 3:5 | -2 | 6 |
| Promotion | |
| Relegation |
