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| 1st(1st leg) | Spartak Myjava | - | Slovan Bratislava | 0:1 (0:1) | ||
| 2nd (2nd leg) | Slovan Bratislava | - | Spartak Myjava | 2:0 (1:0) | ||
| 1st(1st leg): 02/11/2010 13:00 | 2nd (2nd leg): 23/11/2010 16:00 | Winner: Slovan Bratislava | ||||
| 1st(1st leg) | MFK Ružomberok | - | Spartak Trnava | 0:3 (0:1) | ||
| 2nd (2nd leg) | Spartak Trnava | - | MFK Ružomberok | 3:0 (0:0) | ||
| 1st(1st leg): 02/11/2010 14:30 | 2nd (2nd leg): 23/11/2010 16:00 | Winner: Spartak Trnava | ||||
| 1st(1st leg) | FC Nitra | - | Zlaté Moravce | 1:0 (0:0) | ||
| 2nd (2nd leg) | Zlaté Moravce | - | FC Nitra | 2:0 (0:0) | ||
| 1st(1st leg): 02/11/2010 15:00 | 2nd (2nd leg): 23/11/2010 16:00 | Winner: Zlaté Moravce | ||||
| 1st(1st leg) | Tatran Liptovský Mikuláš | - | MŠK Žilina | 0:1 (0:1) | ||
| 2nd (2nd leg) | MŠK Žilina | - | Tatran Liptovský Mikuláš | 3:0 (2:0) | ||
| 1st(1st leg): 10/11/2010 13:00 | 2nd (2nd leg): 01/12/2010 13:00 | Winner: MŠK Žilina | ||||
