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|
| 26/10/2021 | 17:30 | Metalist 1925 Kharkov | - | FC Oleksandriya | 2:5 (0:2) | |
| 27/10/2021 | 12:00 | NK Veres | - | Vorskla Poltava | 1:3 (0:1) | |
| 15:00 | FK Mariupol | - | Dinamo Kiev | 1:2 (0:2) | ||
| 17:30 | Chernomorets Odessa | - | Shakhtar Donetsk | 0:3 (0:0) | ||
| 28/10/2021 | 12:00 | Alians Lypova Dolyna | - | FK Lviv | 2:3 (1:1, 1:1, 1:1) pso | |
| 15:00 | Rukh Lviv | - | Zorya Lugansk | 0:2 (0:0, 0:0) aet | ||
| 17:30 | Metalist Kharkov | - | Kolos Kovalivka | 1:0 (1:0) | ||
| 01/12/2021 | 17:00 | FC LNZ Cherkasy | - | SK Dnipro-1 | 0:2 |
