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| 1st(1st leg) | Real Salt Lake | - | Seattle Sounders | 3:0 (1:0) | ||
| 2nd (2nd leg) | Seattle Sounders | - | Real Salt Lake | 2:0 (0:0) | ||
| 1st(1st leg): 30/10/2011 02:00 | 2nd (2nd leg): 03/11/2011 02:00 | Winner: Real Salt Lake | ||||
| 1st(1st leg) | New York RB | - | Los Angeles Galaxy | 0:1 (0:1) | ||
| 2nd (2nd leg) | Los Angeles Galaxy | - | New York RB | 2:1 (1:1) | ||
| 1st(1st leg): 30/10/2011 19:00 | 2nd (2nd leg): 04/11/2011 03:00 | Winner: Los Angeles Galaxy | ||||
| 1st(1st leg) | Philadelphia Union | - | Houston Dynamo | 1:2 (1:2) | ||
| 2nd (2nd leg) | Houston Dynamo | - | Philadelphia Union | 1:0 (1:0) | ||
| 1st(1st leg): 30/10/2011 21:00 | 2nd (2nd leg): 04/11/2011 00:30 | Winner: Houston Dynamo | ||||
| 1st(1st leg) | Colorado Rapids | - | Sporting Kansas City | 0:2 (0:0) | ||
| 2nd (2nd leg) | Sporting Kansas City | - | Colorado Rapids | 2:0 (1:0) | ||
| 1st(1st leg): 30/10/2011 23:30 | 2nd (2nd leg): 03/11/2011 00:00 | Winner: Sporting Kansas City | ||||
