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| 15/10/2022 | 17:00 | New York RB | - | FC Cincinnati | 1:2 (0:0) | |
| 20:00 | Los Angeles Galaxy | - | Nashville SC | 1:0 (0:0) | ||
| 16/10/2022 | 20:00 | Austin FC | - | Real Salt Lake | 3:1 (1:2, 2:2, 2:2) pso | |
| 17/10/2022 | 01:00 | CF Montréal | - | Orlando City | 2:0 (0:0) | |
| 18/10/2022 | 00:00 | New York City FC | - | Inter Miami CF | 3:0 (0:0) | |
| 02:30 | FC Dallas | - | Minnesota United FC | 5:4 (0:0, 1:1, 1:1) pso |
