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| 1st(1st leg) | Impact de Montréal | - | Austin Aztex | 2:0 (1:0) | ||
| 2nd (2nd leg) | Austin Aztex | - | Impact de Montréal | 2:3 (1:1) | ||
| 1st(1st leg): 07/10/2010 00:30 | 2nd (2nd leg): 10/10/2010 01:30 | Winner: Impact de Montréal | ||||
| 1st(1st leg) | NSC Minnesota Stars | - | Carolina RailHawks | 0:0 (0:0) | ||
| 2nd (2nd leg) | Carolina RailHawks | - | NSC Minnesota Stars | 4:0 (0:0) | ||
| 1st(1st leg): 07/10/2010 00:30 | 2nd (2nd leg): 10/10/2010 00:00 | Winner: Carolina RailHawks | ||||
| 1st(1st leg) | Puerto Rico Islanders | - | Rochester Rhinos | 2:0 (1:0) | ||
| 2nd (2nd leg) | Rochester Rhinos | - | Puerto Rico Islanders | 2:1 (1:1) | ||
| 1st(1st leg): 08/10/2010 01:05 | 2nd (2nd leg): 10/10/2010 00:00 | Winner: Puerto Rico Islanders | ||||
| 1st(1st leg) | Vancouver Whitecaps | - | Portland Timbers | 2:0 (2:0) | ||
| 2nd (2nd leg) | Portland Timbers | - | Vancouver Whitecaps | 1:0 (0:0) | ||
| 1st(1st leg): 08/10/2010 03:30 | 2nd (2nd leg): 11/10/2010 02:00 | Winner: Vancouver Whitecaps | ||||
