North American SuperLiga   M. W D L goals
  Neutral Place 1 0 1 0 1 : 1
  1 0 1 0 1 : 1
Primera División   M. W D L goals
  at home 29 14 9 6 38 : 30
  Away 28 5 11 12 34 : 45
  57 19 20 18 72 : 75
Copa MX   M. W D L goals
  at home 1 1 0 0 2 : 0
  Away 1 0 1 0 0 : 0
  2 1 1 0 2 : 0
overall   M. W D L goals
  at home 30 15 9 6 40 : 30
  Away 29 5 12 12 34 : 45
  Neutral Place 1 0 1 0 1 : 1
  60 20 22 18 75 : 76
North American SuperLiga
2008 Group B Santos Laguna - CF Pachuca 1:1 (0:1)
Primera División
2023/2024 Clausura 16. Round Santos Laguna - CF Pachuca 0:2 (0:0)
2023/2024 Apertura 8. Round CF Pachuca - Santos Laguna 3:2 (1:0)
2022/2023 Clausura Playoffs Recalificación CF Pachuca - Santos Laguna 4:4 (3:2, 4:4) pso
2022/2023 Clausura 14. Round Santos Laguna - CF Pachuca 1:4 (1:2)
2022/2023 Apertura 12. Round CF Pachuca - Santos Laguna 2:0 (0:0)
2021/2022 Clausura 12. Round Santos Laguna - CF Pachuca 3:1 (1:0)
2021/2022 Apertura 13. Round CF Pachuca - Santos Laguna 1:1 (0:0)
2020/2021 Clausura 16. Round CF Pachuca - Santos Laguna 1:0 (0:0)
2020/2021 Apertura Playoffs 1. Round Santos Laguna - CF Pachuca 0:3 (0:1)
2020/2021 Apertura 14. Round Santos Laguna - CF Pachuca 1:1 (1:1)
2019/2020 Clausura 9. Round CF Pachuca - Santos Laguna 1:0 (1:0)
2019/2020 Apertura 9. Round Santos Laguna - CF Pachuca 2:2 (1:2)
2018/2019 Clausura 13. Round Santos Laguna - CF Pachuca 0:0 (0:0)
2018/2019 Apertura 13. Round CF Pachuca - Santos Laguna 1:1 (1:0)
2017/2018 Clausura 15. Round CF Pachuca - Santos Laguna 3:1 (2:1)
2017/2018 Apertura 15. Round Santos Laguna - CF Pachuca 2:2 (1:2)
2016/2017 Clausura 13. Round Santos Laguna - CF Pachuca 1:0 (1:0)
2016/2017 Apertura 13. Round CF Pachuca - Santos Laguna 3:0 (1:0)
2015/2016 Clausura Playoffs Quarter-finals CF Pachuca - Santos Laguna 3:2 (1:1)
2015/2016 Clausura Playoffs Quarter-finals Santos Laguna - CF Pachuca 1:1 (0:1)
2015/2016 Clausura 10. Round Santos Laguna - CF Pachuca 3:2 (3:0)
2015/2016 Apertura 10. Round CF Pachuca - Santos Laguna 0:0 (0:0)
2014/2015 Clausura 16. Round CF Pachuca - Santos Laguna 2:3 (1:1)
2014/2015 Apertura 16. Round Santos Laguna - CF Pachuca 2:1 (1:1)
2013/2014 Clausura Playoffs Semi-finals Santos Laguna - CF Pachuca 4:2 (1:2)
2013/2014 Clausura Playoffs Semi-finals CF Pachuca - Santos Laguna 2:0 (1:0)
2013/2014 Clausura 11. Round Santos Laguna - CF Pachuca 3:1 (0:1)
2013/2014 Apertura 11. Round CF Pachuca - Santos Laguna 1:1 (1:0)
2012/2013 Clausura 6. Round Santos Laguna - CF Pachuca 0:1 (0:1)
2012/2013 Apertura 6. Round CF Pachuca - Santos Laguna 0:0 (0:0)
2011/2012 Clausura 1. Round Santos Laguna - CF Pachuca 0:0 (0:0)
2011/2012 Apertura 1. Round CF Pachuca - Santos Laguna 1:4 (0:3)
2010/2011 Clausura 3. Round Santos Laguna - CF Pachuca 1:1 (1:1)
2010/2011 Apertura 3. Round CF Pachuca - Santos Laguna 0:3 (0:1)
2009/2010 Clausura 10. Round CF Pachuca - Santos Laguna 0:3 (0:0)
2009/2010 Apertura 10. Round Santos Laguna - CF Pachuca 4:0 (1:0)
2008/2009 Clausura 12. Round Santos Laguna - CF Pachuca 2:2 (1:0)
2008/2009 Apertura 12. Round CF Pachuca - Santos Laguna 2:0 (1:0)
2007/2008 Clausura 4. Round Santos Laguna - CF Pachuca 2:1 (2:1)
2007/2008 Apertura 4. Round CF Pachuca - Santos Laguna 0:1 (0:1)
2006/2007 Clausura Playoffs Quarter-finals CF Pachuca - Santos Laguna 1:1 (0:0)
2006/2007 Clausura Playoffs Quarter-finals Santos Laguna - CF Pachuca 1:1 (1:1)
2006/2007 Clausura 16. Round CF Pachuca - Santos Laguna 1:0 (1:0)
2006/2007 Apertura 16. Round Santos Laguna - CF Pachuca 1:1 (0:0)
2005/2006 Clausura 12. Round CF Pachuca - Santos Laguna 0:1 (0:0)
2005/2006 Apertura 12. Round Santos Laguna - CF Pachuca 0:0 (0:0)
2004/2005 Clausura 13. Round Santos Laguna - CF Pachuca 2:0 (2:0)
2004/2005 Apertura 13. Round CF Pachuca - Santos Laguna 2:1 (2:0)
2003/2004 Clausura 15. Round CF Pachuca - Santos Laguna 2:2 (1:1)
2003/2004 Apertura 15. Round Santos Laguna - CF Pachuca 1:2 (1:2)
2002/2003 Clausura 9. Round Santos Laguna - CF Pachuca 2:0 (1:0)
2002/2003 Apertura 9. Round CF Pachuca - Santos Laguna 0:0 (0:0)
2001/2002 Verano 17. Round Santos Laguna - CF Pachuca 3:2 (1:0)
2001/2002 Invierno 17. Round CF Pachuca - Santos Laguna 2:1 (1:0)
2000/2001 Verano Playoffs Final Santos Laguna - CF Pachuca 3:1 (1:1)
2000/2001 Verano Playoffs Final CF Pachuca - Santos Laguna 2:1 (1:1)
2000/2001 Verano 17. Round CF Pachuca - Santos Laguna 2:1
Copa MX
2018/2019 Apertura Group 5 Santos Laguna - CF Pachuca 0:0 (0:0)
2018/2019 Apertura Group 5 CF Pachuca - Santos Laguna 2:0 (2:0)

For games that were decided on penalties the score after 120 minutes will be included in the ranking