CONCACAF Champions Cup   M. W D L goals
  at home 1 0 0 1 1 : 3
  Away 1 0 0 1 0 : 2
  2 0 0 2 1 : 5
Primera División   M. W D L goals
  at home 27 15 7 5 49 : 30
  Away 28 7 6 15 26 : 44
  55 22 13 20 75 : 74
Copa MX   M. W D L goals
  at home 1 0 0 1 1 : 3
  1 0 0 1 1 : 3
overall   M. W D L goals
  at home 29 15 7 7 51 : 36
  Away 29 7 6 16 26 : 46
  Neutral Place 0 0 0 0 0 : 0
  58 22 13 23 77 : 82
CONCACAF Champions Cup
2010/2011 Quarter-finals Santos Laguna - Cruz Azul 1:3 (0:1)
2010/2011 Quarter-finals Cruz Azul - Santos Laguna 2:0 (0:0)
Primera División
2024/2025 Clausura 9. Round Santos Laguna - Cruz Azul 0:1 (0:1)
2024/2025 Apertura 15. Round Cruz Azul - Santos Laguna 2:0 (1:0)
2023/2024 Clausura 11. Round Santos Laguna - Cruz Azul 3:0 (1:0)
2023/2024 Apertura 4. Round Cruz Azul - Santos Laguna 2:2 (2:1)
2022/2023 Clausura 17. Round Cruz Azul - Santos Laguna 3:2 (2:0)
2022/2023 Apertura 7. Round Santos Laguna - Cruz Azul 4:0 (1:0)
2021/2022 Clausura 7. Round Cruz Azul - Santos Laguna 1:2 (0:1)
2021/2022 Apertura 2. Round Santos Laguna - Cruz Azul 1:1 (0:0)
2020/2021 Clausura Playoffs Final Cruz Azul - Santos Laguna 1:1 (0:1)
2020/2021 Clausura Playoffs Final Santos Laguna - Cruz Azul 0:1 (0:0)
2020/2021 Clausura 1. Round Santos Laguna - Cruz Azul 1:0 (0:0)
2020/2021 Apertura 1. Round Cruz Azul - Santos Laguna 2:0 (1:0)
2019/2020 Clausura 3. Round Cruz Azul - Santos Laguna 3:0 (1:0)
2019/2020 Apertura 18. Round Santos Laguna - Cruz Azul 3:1 (2:0)
2018/2019 Clausura 7. Round Cruz Azul - Santos Laguna 1:2 (1:1)
2018/2019 Apertura 7. Round Santos Laguna - Cruz Azul 1:1 (0:0)
2017/2018 Clausura 9. Round Santos Laguna - Cruz Azul 2:0 (0:0)
2017/2018 Apertura 9. Round Cruz Azul - Santos Laguna 2:1 (0:1)
2016/2017 Clausura 6. Round Santos Laguna - Cruz Azul 2:2 (1:1)
2016/2017 Apertura 6. Round Cruz Azul - Santos Laguna 3:1 (0:0)
2015/2016 Clausura 14. Round Cruz Azul - Santos Laguna 0:1 (0:1)
2015/2016 Apertura 14. Round Santos Laguna - Cruz Azul 1:2 (1:1)
2014/2015 Clausura 2. Round Cruz Azul - Santos Laguna 1:0 (0:0)
2014/2015 Apertura 2. Round Santos Laguna - Cruz Azul 1:1 (0:1)
2013/2014 Clausura 2. Round Cruz Azul - Santos Laguna 2:1 (0:1)
2013/2014 Apertura 2. Round Santos Laguna - Cruz Azul 3:2 (3:0)
2012/2013 Clausura Playoffs Semi-finals Cruz Azul - Santos Laguna 2:1 (2:1)
2012/2013 Clausura Playoffs Semi-finals Santos Laguna - Cruz Azul 0:3 (0:2)
2012/2013 Clausura 16. Round Cruz Azul - Santos Laguna 1:0 (1:0)
2012/2013 Apertura 16. Round Santos Laguna - Cruz Azul 2:1 (0:1)
2011/2012 Clausura 11. Round Cruz Azul - Santos Laguna 0:1 (0:1)
2011/2012 Apertura 11. Round Santos Laguna - Cruz Azul 1:0 (1:0)
2010/2011 Clausura 12. Round Santos Laguna - Cruz Azul 3:0 (2:0)
2010/2011 Apertura 12. Round Cruz Azul - Santos Laguna 3:0 (1:0)
2009/2010 Clausura 4. Round Cruz Azul - Santos Laguna 0:2 (0:0)
2009/2010 Apertura 4. Round Santos Laguna - Cruz Azul 3:2 (0:1)
2008/2009 Clausura 9. Round Santos Laguna - Cruz Azul 2:2 (1:1)
2008/2009 Apertura 9. Round Cruz Azul - Santos Laguna 1:1 (0:0)
2007/2008 Clausura Playoffs Final Santos Laguna - Cruz Azul 1:1 (1:0)
2007/2008 Clausura Playoffs Final Cruz Azul - Santos Laguna 1:2 (1:0)
2007/2008 Clausura 1. Round Cruz Azul - Santos Laguna 1:1 (0:1)
2007/2008 Apertura 1. Round Santos Laguna - Cruz Azul 2:0 (2:0)
2006/2007 Clausura 17. Round Santos Laguna - Cruz Azul 2:0 (0:0)
2006/2007 Apertura 17. Round Cruz Azul - Santos Laguna 1:0 (0:0)
2005/2006 Clausura 10. Round Cruz Azul - Santos Laguna 4:1 (2:1)
2005/2006 Apertura 10. Round Santos Laguna - Cruz Azul 3:2 (0:0)
2004/2005 Clausura 17. Round Santos Laguna - Cruz Azul 2:0 (0:0)
2004/2005 Apertura 17. Round Cruz Azul - Santos Laguna 1:0 (0:0)
2003/2004 Clausura 5. Round Santos Laguna - Cruz Azul 3:2 (1:1)
2003/2004 Apertura 5. Round Cruz Azul - Santos Laguna 0:2 (0:2)
2002/2003 Clausura 6. Round Cruz Azul - Santos Laguna 2:2 (1:1)
2002/2003 Apertura 6. Round Santos Laguna - Cruz Azul 1:3 (0:1)
2001/2002 Verano 4. Round Santos Laguna - Cruz Azul 2:2 (2:2)
2001/2002 Invierno 4. Round Cruz Azul - Santos Laguna 0:0 (0:0)
2000/2001 Verano 15. Round Cruz Azul - Santos Laguna 4:0
Copa MX
2016/2017 Clausura Quarter-finals Santos Laguna - Cruz Azul 1:3 (1:3)

For games that were decided on penalties the score after 120 minutes will be included in the ranking