 |
 |
| 2 Fed. 4 | 12/09/2021 | CD San Roque de Lepe | - | CD Coria | 1:2 | ??? |
| 2 Fed. 4 | 26/09/2021 | CD San Roque de Lepe | - | UD Tamaraceite | 1:0 | ??? |
| 2 Fed. 4 | 10/10/2021 | CD San Roque de Lepe | - | CD Mensajero | 4:1 | ??? |
| 2 Fed. 4 | 23/10/2021 | CD San Roque de Lepe | - | UD Montijo | 1:2 | ??? |
| 2 Fed. 4 | 30/10/2021 | CD San Roque de Lepe | - | Córdoba CF | 0:1 | ??? |
| 2 Fed. 4 | 13/11/2021 | CD San Roque de Lepe | - | CF Villanovense | 2:0 | ??? |
| 2 Fed. 4 | 28/11/2021 | CD San Roque de Lepe | - | UD Las Palmas B | 1:1 | ??? |
| Copa del Rey | 01/12/2021 | CD San Roque de Lepe | - | CD Mirandés | 0:3 | ??? |
| 2 Fed. 4 | 12/12/2021 | CD San Roque de Lepe | - | AD Ceuta FC | 2:2 | ??? |
Spain