 |
 |
| SL2 | 16/01/2021 | AE Karaiskakis | - | Levadiakos | 0:2 | ??? |
| SL2 | 24/01/2021 | AE Karaiskakis | - | PAE Chania | 1:1 | ??? |
| SL2 | 31/01/2021 | AE Karaiskakis | - | Ergotelis | 0:1 | ??? |
| SL2 | 10/02/2021 | AE Karaiskakis | - | Xanthi FC | 0:1 | ??? |
| SL2 | 17/02/2021 | AE Karaiskakis | - | AO Trikala | 1:0 | ??? |
| SL2 | 07/03/2021 | AE Karaiskakis | - | OFI Ierapetra | 2:3 | ??? |
| SL2 | 17/03/2021 | AE Karaiskakis | - | Panachaiki GE | 0:0 | ??? |
| SL2 | 28/03/2021 | AE Karaiskakis | - | Apollon Lárissa | 1:2 | ??? |
| SL2 | 07/04/2021 | AE Karaiskakis | - | Ionikos Nikea | 0:3 | ??? |
| SL2 | 18/04/2021 | AE Karaiskakis | - | Doxa Dramas FC | 1:1 | ??? |
| SL2 | 21/04/2021 | AE Karaiskakis | - | Diagoras FC | 2:1 | ??? |
| SL2 | 04/05/2021 | AE Karaiskakis | - | Panachaiki GE | 3:3 | ??? |
| SL2 | 18/05/2021 | AE Karaiskakis | - | OFI Ierapetra | 0:3 | ??? |
| Kypello | 26/09/2021 | AE Karaiskakis | - | Xanthi FC | 0:2 | ??? |
| SL2 | 13/11/2021 | AE Karaiskakis | - | AE Kifisias | 0:2 | ??? |
| SL2 | 24/11/2021 | AE Karaiskakis | - | PS Kalamata | 0:1 | ??? |
| SL2 | 11/12/2021 | AE Karaiskakis | - | Ergotelis | 3:2 | ??? |
| SL2 | 19/12/2021 | AE Karaiskakis | - | Diagoras FC | 0:0 | ??? |
Greece