2. Round
14/09/2021 14:00 FC Olimpia - FC Sîngerei 1:3
14:00 CS Cruiz-Plus - FCM Ungheni 1:4
14:00 ARF Ocniţa - Speranța Drochia 0:4
14:00 FC Real-Succes - Olimp Comrat 1:8
14:00 FC Saxan - Sporting Trestieni 3:2 aet
14:00 FC Maiak Chirsova - FC Cahul 2005 2:4
14:00 Spartanii Sportul - Dacia Buiucani 2:0 aet
14:00 CF Soroca - Victoria Bardar 0:1
Round of 16
26/10/2021 11:00 FC Sfîntul Gheorghe - Victoria Bardar 1:0
11:00 CS Petrocub - Olimp Comrat 6:0
11:00 Spartanii Sportul - Dinamo-Auto 1:3
13:00 FC Bălţi - FC Cahul 2005 3:0 dec.
27/10/2021 11:00 FC Floreşti - FC Sîngerei 3:1
11:00 Speranța Drochia - FC Zimbru 1:4
13:00 FC Milsami - FCM Ungheni 5:1
13:00 FC Sheriff - FC Saxan 6:0
Quarter-finals
12/04/2022 FC Sfîntul Gheorghe - FC Floreşti 3:0 dec.
16:00 FC Sheriff - CS Petrocub 4:0
13/04/2022 14:00 FC Zimbru - FC Milsami 0:3
16:00 FC Bălţi - Dinamo-Auto 3:4 pso
Semi-finals
26/04/2022 14:00 Dinamo-Auto - FC Sheriff 2:3
17:00 FC Milsami - FC Sfîntul Gheorghe 0:2
Final
21/05/2022 18:00 FC Sfîntul Gheorghe - FC Sheriff 0:1 (0:0)
Cupa Moldova
Cupa Moldova