| 1. Round | 14/08/2021 | Hatayspor | - | Kasımpaşa SK | 1:1 | ||||
| 2. Round | 23/08/2021 | Galatasaray | - | Hatayspor | 2:1 | ||||
| 3. Round | 28/08/2021 | Hatayspor | - | Alanyaspor | 5:0 |  |
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| 4. Round | 12/09/2021 | Çaykur Rizespor | - | Hatayspor | 0:2 | ||||
| 5. Round | 19/09/2021 | Hatayspor | - | Kayserispor | 2:1 | ||||
| 6. Round | 22/09/2021 | Göztepe | - | Hatayspor | 0:2 | ||||
| 7. Round | 26/09/2021 | Hatayspor | - | Fenerbahçe | 1:2 | ||||
| 8. Round | 03/10/2021 | Yeni Malatyaspor | - | Hatayspor | 0:2 | ||||
| 9. Round | 18/10/2021 | Hatayspor | - | Gaziantep FK | 2:1 | ||||
| 10. Round | 24/10/2021 | Fatih Karagümrük | - | Hatayspor | 1:1 | ||||
| 11. Round | 30/10/2021 | Hatayspor | - | Beşiktaş | 1:0 | |
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| 12. Round | 07/11/2021 | Adana Demirspor | - | Hatayspor | 1:0 | ||||
| 13. Round | 20/11/2021 | Hatayspor | - | Antalyaspor | 3:1 | ||||
| 14. Round | 28/11/2021 | Sivasspor | - | Hatayspor | 4:0 | ||||
| 15. Round | 05/12/2021 | Hatayspor | - | İstanbul Başakşehir | 0:3 | |
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| 19. Round | 25/12/2021 | Giresunspor | - | Hatayspor | 0:1 | ||||
| 24. Round | 04/02/2022 | Kayserispor | - | Hatayspor | 4:3 | |
Mali
