| 1. Round | 15/08/2004 | San Lorenzo | - | Olimpo de Bahía Blanca | 1:1 | ||||
| 2. Round | 22/08/2004 | Boca Juniors | - | San Lorenzo | 3:0 | ||||
| 3. Round | 25/08/2004 | San Lorenzo | - | Gimnasia de La Plata | 3:0 |  |
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| 4. Round | 29/08/2004 | Independiente | - | San Lorenzo | 2:2 |  |
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| 5. Round | 12/09/2004 | San Lorenzo | - | Vélez Sarsfield | 1:0 | |
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| 7. Round | 23/09/2004 | San Lorenzo | - | Huracán de Tres Arroyos | 4:1 | ||||
| 8. Round | 26/09/2004 | Colón de Santa Fe | - | San Lorenzo | 3:0 | ||||
| 9. Round | 02/10/2004 | San Lorenzo | - | Banfield | 3:1 | ||||
| 10. Round | 16/10/2004 | Argentinos Juniors | - | San Lorenzo | 1:0 | ||||
| 11. Round | 20/10/2004 | San Lorenzo | - | Instituto de Córdoba | 2:0 | ||||
| 12. Round | 24/10/2004 | River Plate | - | San Lorenzo | 1:2 | ||||
| 16. Round | 20/11/2004 | Quilmes | - | San Lorenzo | 1:1 | ||||
| 17. Round | 28/11/2004 | San Lorenzo | - | Almagro | 1:1 | ||||
| 18. Round | 05/12/2004 | Lanús | - | San Lorenzo | 2:3 | ||||
| 19. Round | 12/12/2004 | San Lorenzo | - | Racing Club | 4:1 |
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