| 2. Round | 27/02/2021 | Deportivo Cuenca | - | Guayaquil City | 3:0 | ||||
| 4. Round | 13/03/2021 | Delfín SC | - | Guayaquil City | 1:1 |  |
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| 5. Round | 21/03/2021 | Guayaquil City | - | Universidad Catolica | 1:2 | ||||
| 7. Round | 31/03/2021 | Guayaquil City | - | Orense SC | 4:1 | ||||
| 6. Round | 04/04/2021 | Técnico Universitario | - | Guayaquil City | 3:0 | ||||
| 10. Round | 04/05/2021 | Olmedo | - | Guayaquil City | 0:0 | ||||
| 11. Round | 11/05/2021 | Guayaquil City | - | Manta | 0:3 | ||||
| 12. Round | 16/05/2021 | Emelec | - | Guayaquil City | 1:0 | |
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| 13. Round | 22/05/2021 | Independiente del Valle | - | Guayaquil City | 3:0 | ||||
| 14. Round | 29/05/2021 | Guayaquil City | - | Mushuc Runa | 0:0 |
Uruguay