| 2. Round | 23/07/2021 | Defensa y Justicia II | - | Godoy Cruz II | 2:1 | ||||
| 3. Round | 27/07/2021 | Godoy Cruz II | - | Atlético Tucumán II | 2:2 | ||||
| 5. Round | 06/08/2021 | Godoy Cruz II | - | River Plate II | 0:1 | ||||
| 6. Round | 13/08/2021 | Lanús II | - | Godoy Cruz II | 5:1 | ||||
| 7. Round | 20/08/2021 | Godoy Cruz II | - | Huracán II | 2:1 | ||||
| 10. Round | 05/09/2021 | Godoy Cruz II | - | Gimnasia de La Plata II | 3:0 | ||||
| 11. Round | 13/09/2021 | Aldosivi II | - | Godoy Cruz II | 1:2 | ||||
| 12. Round | 17/09/2021 | Godoy Cruz II | - | Sarmiento de Junín II | 0:0 | ||||
| 13. Round | 23/09/2021 | Independiente II | - | Godoy Cruz II | 0:0 | ||||
| 17. Round | 19/10/2021 | Boca Juniors II | - | Godoy Cruz II | 6:0 | ||||
| 20. Round | 05/11/2021 | Godoy Cruz II | - | Talleres de Córdoba II | 1:1 | ||||
| 9. Round | 11/11/2021 | Vélez Sarsfield II | - | Godoy Cruz II | 3:0 | ||||
| 24. Round | 03/12/2021 | Godoy Cruz II | - | Platense II | 0:2 |
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