1. Round | 14/08/2021 | İstanbulspor AŞ | - | Manisa FK | 3:4 | ||||
2. Round | 22/08/2021 | Manisa FK | - | Denizlispor | 1:0 | ||||
3. Round | 29/08/2021 | Gençlerbirliği | - | Manisa FK | 0:3 | ||||
4. Round | 11/09/2021 | Manisa FK | - | BB Erzurumspor | 0:1 | ||||
5. Round | 15/09/2021 | Menemen Belediyespor | - | Manisa FK | 2:0 | ||||
6. Round | 18/09/2021 | Manisa FK | - | Bandırmaspor | 1:3 | ||||
7. Round | 25/09/2021 | Ümraniyespor | - | Manisa FK | 1:0 | ||||
8. Round | 03/10/2021 | Eyüpspor | - | Manisa FK | 3:2 | ||||
9. Round | 17/10/2021 | Manisa FK | - | Adanaspor | 0:3 | ||||
11. Round | 30/10/2021 | Manisa FK | - | Boluspor | 2:2 | ||||
12. Round | 06/11/2021 | Samsunspor | - | Manisa FK | 1:0 | ||||
13. Round | 21/11/2021 | Manisa FK | - | Altınordu FK | 1:0 | ||||
14. Round | 26/11/2021 | Balıkesirspor | - | Manisa FK | 0:0 | ||||
16. Round | 11/12/2021 | Bursaspor | - | Manisa FK | 1:1 | ||||
17. Round | 14/12/2021 | Manisa FK | - | Keçiörengücü | 1:1 |