| 2. Round | 19/02/2021 | Newell's Old Boys II | - | Boca Juniors II | 1:3 | ||||
| 4. Round | 05/03/2021 | Newell's Old Boys II | - | Independiente II | 1:2 | ||||
| 8. Round | 02/04/2021 | Newell's Old Boys II | - | Huracán II | 3:0 | ||||
| 12. Round | 30/04/2021 | Rosario Central II | - | Newell's Old Boys II | 0:2 |
Argentina