| 2. Round | 18/09/2019 | Cerro Largo | - | Defensor Sporting | 1:4 | ||||
| 3. Round | 22/09/2019 | Defensor Sporting | - | Rampla Juniors | 1:0 | ||||
| 4. Round | 06/10/2019 | Juventud de Las Piedras | - | Defensor Sporting | 1:3 |  |
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| 5. Round | 11/10/2019 | Defensor Sporting | - | Liverpool | 0:0 |  |
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| 6. Round | 17/10/2019 | Montevideo Wanderers | - | Defensor Sporting | 2:0 | ||||
| 7. Round | 20/10/2019 | Defensor Sporting | - | Racing | 4:0 | ||||
| 8. Round | 25/10/2019 | Boston River | - | Defensor Sporting | 1:4 | |
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| 9. Round | 02/11/2019 | Defensor Sporting | - | Danubio | 1:2 | ||||
| 10. Round | 06/11/2019 | Plaza Colonia | - | Defensor Sporting | 4:1 | ||||
| 11. Round | 10/11/2019 | Defensor Sporting | - | CA Cerro | 1:1 | |
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| 12. Round | 16/11/2019 | River Plate | - | Defensor Sporting | 1:0 | ||||
| 13. Round | 21/11/2019 | Defensor Sporting | - | Nacional | 2:1 | ||||
| 14. Round | 28/11/2019 | Fénix | - | Defensor Sporting | 3:2 | ||||
| 15. Round | 05/12/2019 | Defensor Sporting | - | Progreso | 2:4 | |
Uruguay
Italy