| 6. Round | 15/08/2021 | Rosario Central | - | Independiente | 1:2 | ||||
| 7. Round | 21/08/2021 | Independiente | - | Defensa y Justicia | 0:0 | ||||
| 8. Round | 24/08/2021 | Atlético Tucumán | - | Independiente | 2:0 | ||||
| 9. Round | 29/08/2021 | Independiente | - | Colón de Santa Fe | 3:0 |  |
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| 10. Round | 06/09/2021 | River Plate | - | Independiente | 1:1 | ||||
| 11. Round | 13/09/2021 | Independiente | - | Lanús | 0:1 | ||||
| 12. Round | 19/09/2021 | Huracán | - | Independiente | 0:1 | |
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| 13. Round | 26/09/2021 | Independiente | - | Godoy Cruz | 1:4 | ||||
| 14. Round | 03/10/2021 | Vélez Sarsfield | - | Independiente | 3:3 | ||||
| 15. Round | 11/10/2021 | Independiente | - | Gimnasia de La Plata | 1:1 | ||||
| 16. Round | 17/10/2021 | Aldosivi | - | Independiente | 1:0 | ||||
| 17. Round | 21/10/2021 | Independiente | - | Sarmiento de Junín | 1:1 | ||||
| 18. Round | 26/10/2021 | Independiente | - | Unión de Santa Fe | 1:0 | ||||
| 19. Round | 31/10/2021 | Newell's Old Boys | - | Independiente | 1:0 | ||||
| 20. Round | 06/11/2021 | Independiente | - | Arsenal de Sarandí | 3:0 | |
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| 24. Round | 05/12/2021 | Independiente | - | San Lorenzo | 1:1 |  |
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| 25. Round | 13/12/2021 | Talleres de Córdoba | - | Independiente | 1:2 |
USA
Argentina