| 3. Round | 22/01/2022 | CF América [U18] | - | Atlas Guadalajara [U18] | 0:0 | ||||
| 6. Round | 20/02/2022 | Atlas Guadalajara [U18] | - | Pumas UNAM [U18] | 5:2 | ||||
| 7. Round | 25/02/2022 | Club Tijuana [U18] | - | Atlas Guadalajara [U18] | 3:3 | ||||
| 8. Round | 02/03/2022 | Atlas Guadalajara [U18] | - | CF Pachuca [U18] | 2:1 | ||||
| 9. Round | 05/03/2022 | Gallos Blancos [U18] | - | Atlas Guadalajara [U18] | 0:1 | ||||
| 10. Round | 11/03/2022 | FC Juárez [U18] | - | Atlas Guadalajara [U18] | 0:3 |  |
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| 11. Round | 20/03/2022 | Atlas Guadalajara [U18] | - | Deportivo Guadalajara [U18] | 0:0 | ||||
| 12. Round | 02/04/2022 | Cruz Azul [U18] | - | Atlas Guadalajara [U18] | 1:1 | ||||
| 13. Round | 07/04/2022 | Atlas Guadalajara [U18] | - | Club Necaxa [U18] | 1:3 | ||||
| 14. Round | 14/04/2022 | Atlas Guadalajara [U18] | - | Mazatlán FC [U18] | 4:1 | ||||
| 15. Round | 20/04/2022 | CF Monterrey [U18] | - | Atlas Guadalajara [U18] | 0:2 | ||||
| 16. Round | 24/04/2022 | Deportivo Toluca [U18] | - | Atlas Guadalajara [U18] | 1:0 |  |
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| 17. Round | 30/04/2022 | Atlas Guadalajara [U18] | - | UANL Tigres [U18] | 3:0 |
Mexico