| 1. Round | 10/01/2022 | FC Juárez [Women] | - | Atlético San Luis [Women] | 0:1 | ||||
| 8. Round | 27/02/2022 | FC Juárez [Women] | - | Deportivo Toluca [Women] | 0:1 | ||||
| 10. Round | 13/03/2022 | Puebla FC [Women] | - | FC Juárez [Women] | 2:1 | ||||
| 11. Round | 17/03/2022 | FC Juárez [Women] | - | Mazatlán FC [Women] | 1:1 | ||||
| 12. Round | 21/03/2022 | Atlas Guadalajara [Women] | - | FC Juárez [Women] | 2:1 |  |
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| 13. Round | 27/03/2022 | FC Juárez [Women] | - | Pumas UNAM [Women] | 1:0 | ||||
| 14. Round | 01/04/2022 | CF América [Women] | - | FC Juárez [Women] | 2:1 | ||||
| 9. Round | 11/04/2022 | Deportivo Guadalajara [Women] | - | FC Juárez [Women] | 0:0 | ||||
| 15. Round | 18/04/2022 | FC Juárez [Women] | - | Gallos Blancos [Women] | 2:1 | ||||
| 16. Round | 26/04/2022 | Santos Laguna [Women] | - | FC Juárez [Women] | 3:1 | |
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| 17. Round | 03/05/2022 | Club Tijuana [Women] | - | FC Juárez [Women] | 3:2 |
Mexico