| 1. Round | 11/01/2022 | CF América [Women] | - | Atlas Guadalajara [Women] | 1:1 | ||||
| 2. Round | 17/01/2022 | Atlas Guadalajara [Women] | - | Mazatlán FC [Women] | 1:1 | ||||
| 3. Round | 22/01/2022 | Atlas Guadalajara [Women] | - | Santos Laguna [Women] | 1:0 | ||||
| 4. Round | 29/01/2022 | UANL Tigres [Women] | - | Atlas Guadalajara [Women] | 5:1 | ||||
| 5. Round | 31/01/2022 | Atlas Guadalajara [Women] | - | Puebla FC [Women] | 1:0 | ||||
| 6. Round | 07/02/2022 | Club Necaxa [Women] | - | Atlas Guadalajara [Women] | 1:1 | ||||
| 7. Round | 12/02/2022 | Atlas Guadalajara [Women] | - | Atlético San Luis [Women] | 1:1 | ||||
| 13. Round | 26/03/2022 | Cruz Azul [Women] | - | Atlas Guadalajara [Women] | 2:1 | ||||
| 17. Round | 02/05/2022 | Atlas Guadalajara [Women] | - | Club León [Women] | 2:1 |
Mexico